Problems and their solution in the final stage of the Global Program to Eliminate Lymphatic Filariasis

已发现使用尿液样本的免疫诊断（尿液ELISA）在发现丝虫病低度流行地区的感染者方面是有效的。该方法可用于确定丝虫病的消除或监测丝虫病的复发。还开发了一种新的基于尿液的视觉诊断（珠方法）。它可以在没有先进设备的地区取代尿液ELISA。建立了一种检测蚊媒中丝虫DNA的LAMP方法。这些新方法将有助于发现“隐藏的”地方病疫源地，从而在消灭计划的最后阶段作出巨大贡献。

An immunodiagnosis using urine samples(urine ELISA) has been found effective in finding out filaria-infected individuals in very low endemic areas. The method will be useful to confirm elimination of filariasis or detect its resurgence. A new urine-based, visual diagnosis(beads method) has also been developed. It can replace urine ELISA in areas where sophisticated equipment is not available. A LAMP method to detect filarial DNA in mosquito vectors has been developed. These new methods will help discover "hidden" endemic foci, and thus contribute greatly in the final stage of the elimination program.