Search for new susceptibility gene controlled of cleft and/or palate development using p53 knock-out mice

我们受苦于MSM p53基因敲除小鼠的生产。我们继续不断地研究，并计划实现一个目的。而P53基因分型和利用微卫星标记进行聚合酶链式反应的条件已基本确定。我们的目标是通过调整条件的顺序来稳定分型，目前还没有发现新的唇腭裂促进的易感基因，但通过继续这项研究，可以识别出适用的基因簇，进行功能分析，以及对临床做出贡献的可能性。

We suffer from MSM p53 knockout mouse production. We continue a study continuously and are planning to achieve a purpose. Whereas the condition establishment of p53 typing and the PCR which we used microsatellite marker for was almost decided. We aim at the stable typing by adjusting a condition sequentially.It have not lead to the identification of new susceptibility gene for cleft lip and palate promotion yet, but the identification of the applicable gene cluster, analysis of function, likelihood of the contribution to a clinical were shown in future by continuing this study.