Molecular mechanism of cyto-differentiation of proliferating bone resorping lesions

我们检测了Notch信号分子Notch1和Jagged1，在典型的实性/多囊性成釉细胞瘤的连续大病例中。综上所述，这些形态发生调控因子与成釉细胞瘤细胞分化密切相关。Notch和锯齿状阳性细胞比率在不同的组织病理学和细胞学模式中几乎相同，但分化较低的细胞数量略少于分化较好的细胞。

We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In summary, the results showed that these morphogenesis regulation Notch and related factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratio was frequently positive, and was nearly the same between the varied histopathological, cytological patterns; however, the less-differentiated cells were slightly fewer in number that that of well-differentiated cells.