Ribavirin regulates hepatitis C virus replication through the up-regulation of interferon-stimulated genes

干扰素（IFN）和利巴韦林（RBV）联合治疗用于治疗HCV感染，然而，RBV如何增强抗HCV作用仍然未知。因此，我们研究了RBV是否会改变IFN的抗hcv作用。我们使用基于质粒的HCV复制系统，在HepG2和Huh7肝癌细胞系中表达HCV基因型1a全基因组。利巴韦林通过提高自分泌IFN-β诱导的isg上调来调节HCV复制。RBV对isg的调制将有助于建立一种消除HCV的方法。

The combination therapy of interferon (IFN) and ribavirin (RBV) is used to treat HCV infection, however, how RBV enhances the anti-HCV effects remains unknown. We therefore investigated whether RBV modifies IFN's anti-HCV action. We used plasmid-based HCV replication system, which express HCV genotype 1a full genome in HepG2 and Huh7 hepatoma cell lines. Ribavirin regulates HCV replication through the up-regulation of ISGs induced by enhancing autocrine IFN-β. The modulation of ISGs by RBV would help to establish a means of eliminating HCV.