Strategy for treatment of periodontitis with regulating exocytosis using functional bionano particle

我们探索了牙龈上皮细胞胞内囊泡运输的因素，并检查了调节的可能性。小g蛋白Rab5和相关蛋白vinculin被确定为细胞内囊泡运输的重要因子。Rab5和ICAM-1与细胞对牙龈卟啉单胞菌的摄取有关。此外，我们澄清了e -选择素在通过牙龈假单胞菌刺激调节内皮细胞胞吐的重要作用。

We explored factors for intracellular vesicle trafficking in gingival epithelial cells and examined a possibility of the regulation. A small G-protein Rab5 and the associated protein vinculin were identified as important factors for vesicle trafficking in the cells. Rab5 and ICAM-1 were associated with uptake of Porphyromonas gingivals by the cells. Furthermore, we clarified that E-selectin is important for regulating endothelial exocytosis by stimulation with P. gingivalis.