Development of novel material for caries treatment using mineral-inducing monomers

使用开发的用于牙本质再矿化的单体，我们评价了它们的矿化诱导能力和含有单体的树脂的短期/长期牙本质粘结强度，并观察了粘附界面。此外，我们还研究了含有该单体的材料的牙本质粘附性能和封闭能力，以抑制牙本质过敏。结果发现，在树脂中加入5%和10%的开发单体、AK-100和TSM-47，可使磷灰石晶体在粘附界面沉积，牙本质粘附力强，表明粘附界面具有长期耐久性。因此，建议通过使用矿物质诱导单体，基于对脱矿牙本质的最小干预的修复治疗是可能的。

Using monomers which were developed for dentin remineralization, we evaluated their mineral-induction ability and short-/long-term dentin bond strength of resin containing the monomers, and observed adhesion interface. Moreover, we examined dentin adhesive property and sealing ability of material containing the monomer for inhibition of dentin hypersensitivity.In results, it was found that addition of 5 and 10% of the developed monomer, AK-100 and TSM-47 to resin causes the deposition of apatite crystals in the adhesion interface, strong dentin adhesion, indicating long-term durability of adhesion interface.Therefore, it was suggested that restorative treatment based upon minimal intervention to demineralized dentin might be possible by using the mineral-inducing monomers.