Investigation of neuropathology of synucleinopathies using novel model mice.

为了建立有效的帕金森病（PD）和路易体痴呆（DLB）动物模型，制备了过表达路易体痴呆（DLB）相关βsyn（P123 H）的转基因（Tg）小鼠，并对其进行了分析。βsyn（P123 H）Tg小鼠主要表现为非运动症状，而过表达βsyn（P123 H）/αsyn的小鼠表现为广泛的表型，包括神经细胞死亡。该模型可作为研究PD和DLB发病机制的有力工具。

To establish useful model animal of Parkinson's Disease(PD) and dementia with Lewy bodies(DLB), transgenic(Tg) mice overexpressing dementia with Lewy bodies(DLB)-linkedβsyn(P123H) were made and analyzedβsyn(P123H) Tg mice mainly showed non-motor symptoms, whereas mice overexpressingβsyn(P123H)/αsyn were characterized by extensive phenotypes, including neuronal cell death. These mice model could be a powerful tool with which to investigate the pathogenic mechanism of PD and DLB.