Development of cancer molecular therapeutics that targets telomere-regulating factors

本研究旨在设计一种端粒导向的癌症治疗方法。我们的主要研究结果发现，G-四链体配体可诱导胶质瘤干细胞的DNA损伤和转录畸变，并抑制胶质瘤干细胞的生长。我们还发现，自组装的端锚聚合酶，端粒延长的正调控抑制其功能。此外，我们发现，表现出端粒相关因子WRN和POT 1低表达的癌细胞对抗微管药物敏感。这些结果将适用于开发新的癌症化疗药物

This study aims to design a telomere-directed cancer therapy. As main results, we found that G-quadruplex ligands induce DNA damage and transcriptional aberration and inhibit growth of glioma stem cells. We also found that self-assembly of tankyrase, a positive regulator of telomere elongation represses its function. Furthermore, we found that cancer cells that exhibit low expression of telomere-related factors, WRN and POT1, are sensitive to anti-microtubule drugs. These results would be applicable to development of new cancer chemotherapy