A study of the ameliorative activity of 2-decenoic acid ester derivatives on the spinal cord injury and its medical application

口服(E)- n -2-（二甲氨基）乙基癸烯-2-烯酰胺（一种新型的2-癸烯酸化合物）给全断脊髓损伤大鼠3周后，运动能力明显改善。经2-十烯酸衍生物治疗后，脊髓损伤后运动功能受损的大鼠基本能保持其后肢重量行走，而未经治疗的对照组则基本保持不变，说明口服2-十烯酸衍生物可明显恢复脊髓损伤后的运动功能受损。

Oral administration of (E)-N-2-(dimethylamino) ethyl dec-2-enamide, a novel 2-decenoic acid compound, to the rats with a complete transection of the spinal cord injury, markedly improved locomotor activity after 3 weeks. The animals treated with the compound could nearly walk sustaining their weight in hind limb, but the control ones without treatment remained unchanged, demonstrating that the locomotor function impaired following the spinal cord injury could be markedly recovered by oral administration of the 2-decenoic acid derivatives.