Analysis of the regulatory mechanism for differentiation and functionof macrophages using a novel cytokine IL-34

巨噬细胞是调节先天免疫的重要造血免疫细胞，其分化和功能受称为细胞因子的功能性蛋白质的调节。到目前为止发现的一个主要细胞因子是M-CSF，但最近发现另一种细胞因子IL-34也调节巨噬细胞的分化和功能。在本研究中，我们揭示了这两种细胞因子对巨噬细胞的不同调节作用，提示M-CSF和IL-34在体内具有不同的作用

Macrophages are important hematopoietic immune cells that regulateinnate immunity, and their differentiation and function are regulated by functionalproteins called cytokines. A major cytokine identified so far is M-CSF, but it has beenrecently found that another cytokine IL-34 also regulates macrophage differentiation andfunction. In this study, we revealed that these two cytokines differentially regulatedmacrophages, suggesting that M-CSF and IL-34 have different in vivo role