The study of pathogenesis and related molecules of IgG4 related disease and development of treatment modality.

IgG4相关性硬化性涎腺炎是新近发现的一种疾病，其特征是血清中IgG4浓度升高，病变器官中产生IgG4的浆细胞扩张，表现为纤维化或硬化性改变。然而，对CD4+和CD8+T细胞或IL-17在该病中的作用知之甚少。本研究旨在探讨IgG4相关性硬化性涎腺炎患者外周血中CD4+、CD8+T细胞及IL-17的变化特点。我们的发现显示，在IgG4相关的硬化性涎腺炎患者中，Th1和Tc1细胞占优势，IL-17过度表达。这一观察强调了Th1和Tc1细胞以及IL-17参与了本病的发病机制。识别它们的精确功能特性将极大地增强我们对它们致病作用的理解。有必要对这些亚群进行详细的表型和功能分析。

IgG4-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or IL-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. Our findings revealed a predominance of Th1 and Tc1 cells and overexpression of IL-17 in patients with IgG4-related sclerosing sialadenitis. This observation emphasizes the involvement of Th1 and Tc1 cells and IL-17 in the pathogenesis of this disease. Identify their precise functional properties would greatly enhance our understanding of their pathogenetic roles. A detailed phenotypic and functional analysis of these subsets is warranted.