Dissecting the Factors Involved in the Locomotion Mode of Neuronal Migration in the Developing Cerebral Cortex

神经元迁移对于皮层的形成是必不可少的，因为迁移缺陷会导致神经系统疾病。神经元迁移的运动方式覆盖了大部分的迁移路径，因此是皮层形成的主要贡献者。然而，很难分析调控这种模式的分子机制。在本研究中，我们使用了离体化学抑制剂筛选，可以直接分析迁移的运动模式，并发现了几个调节运动模式的调节分子。

Neuronal migration is essential for proper cortical layer formation, as migration defects result in neurological disorders. The locomotion mode of neuronal migration covers most of the migration route and thereby is the main contributor to cortical layer formation. However, analysis of the molecular mechanisms regulating this mode is difficult. In this study, we used an ex vivo chemical inhibitor screening, allowing us to directly analyze the locomotion mode of migration, and found several regulatory molecules regurating the locomotion mode.