Elucidation of the nerve - immune system mechanism of facial cancer-induced pain in nucleus of spinal tract of trigeminal nerve.

许多晚期和晚期癌症患者必须应对慢性疼痛。在口面部癌症患者中，疼痛很容易导致比其他部位的癌症更严重的症状。由于癌性疼痛有时难以治愈，因此迫切需要提高无法治愈的癌症患者的生活质量，寻求预防癌性疼痛发展的手段。因此，为了研究癌症对三叉神经的影响，我们建立了大鼠面部癌症模型，揭示了面部癌症引起的疼痛机制的一些特点。

Many advanced and terminal cancer patients must cope with chronic pain. In orofacial cancer patients, pain can readily lead more severe symptoms than found in cancers of other regions. Because cancer pain is sometimes intractable, there is an urgent need to improve the quality of life of patients with incurable cancer and seek means to prevent the development of cancer pain. Therefore, to study effect of cancer on the trigeminal nerve, we have developed a rat facial cancer model and have revealed some characteristics in the mechanisms of facial cancer-induced pain.