Trichloroethylene-induced hypersensitivity may be caused by its active metabolite-protein adducts

在哈特利豚鼠最大化试验中，我们研究了与三氯乙烯、三氯乙醇和三氯乙酸诱发的皮肤过敏反应相关的皮肤和肝脏损伤。三氯乙烯致敏率雄性豚鼠为70%，雌性豚鼠为90%。三氯乙醇对雄性豚鼠的致敏率为20%，对雌性豚鼠的致敏率为50%，而三氯乙酸对豚鼠的致敏率仅为轻微。与致敏有关，皮肤可见嗜酸性细胞，肝脏局灶性坏死周围可见淋巴细胞浸润。这些变化在暴露于三氯乙烯的动物中最为明显，其次是三氯乙醇。三氯乙烯暴露也增加了血浆γ - gtp和干扰素γ水平，而三氯乙醇和三氯乙酸则没有。

We investigated skin and liver damages associated with trichloroethylene-, trichloroethanol-and trichloroacetic acid-induved hypersensitive skin reactions in the hartley guinea pig maximization test. The sensitization rates of trichloroethylene-induced dermal allergy were 70% in male guinea pigs, and 90% in female ones. Those of trichloroethanol were 20% in male guinea and 50% in female ones, while only a minor sensitization was seen after trichloroacetic acid treatment. In relation to the sensitization, eosinocytes were seen in the skin, and infiltration of lymphocytes was seen around focal necrosis in the liver. These changes were seen most prominent in trichloroethylene-exposed animals, followed by trichloroethanol. Trichloroethylene exposure also increased plasmaγGTP and interferonγlevels, while trichloroethanol and trichloroacetic acid did not.