Mechanisms of abnormal organogenesis and histogenesis of the kidney and ureter and development of the embryonic treatment

我们已经阐明，包括趋同延伸在内的细胞重排与输尿管的延伸和肾脏的“抬高”有关，并在输尿管增殖上皮细胞中观察到核迁移样的相互动力学核运动。外子宫操作/发育系统是一种用于修饰包括输尿管在内的器官发生和组织发生的方法，它通过回声引导和其他改进得到了改进，以便更准确地靶向注射。虽然我们在输尿管相关的实验中没有得到结论性的结果，但我们可以成功地在肌肉骨骼系统的实验中修饰组织发生。

We have clarified that cell rearrangements including convergent extension are involved in elongation of the ureter and ‘elevation’ of the kidney, and observed interkinetic nuclear migration-like nuclear movement in the proliferating epithelial cells of the ureter. The exo-utero manipulation/development system, a method to modify the organogenesis and histogenesis of organs including the ureter, has been improved by echo-guidance and other refinements for the more accurately targeted injection. Although we could not obtain conclusive results in the ureter-related experiments, we could successfully modify the histogenesis in the experiments of the musculoskeletal system.