Diet, genes, and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

我们在长野和圣保罗的病例对照研究中检验了绿茶、钙、维生素D摄入量与乳腺癌风险之间的关系。我们利用与这些饮食因素相关的遗传多态性进一步研究了基因与环境的相互作用。没有发现绿茶摄入量和乳腺癌风险之间的显著关联，也没有观察到潜在的遗传效应修饰因子之间的显著相互作用。研究表明，钙和维生素D的摄入量与乳腺癌风险呈负相关。我们利用与维生素D受体基因和血液中维生素D水平相关的遗传多态性研究了基因与环境的相互作用。

We examined the association between green tea, calcium, vitamin D intake and the risk of breast cancer in case-control studies in Nagano and Sao Paulo. We further investigated gene-environment interaction using genetic polymorphisms related to these dietary factors. No significant association was found between green tea consumption and breast cancer risk and no significant interaction was observed by potential genetic effect modifiers. An inverse association was suggested between calcium and vitamin D intake, and breast cancer risk. We have investigated gene-environment interaction using genetic polymorphisms related to vitamin D receptor gene and blood level of vitamin D.