Tissue Reconstruction Based on Adaptive Remodeling

随着人口老龄化，患有结缔组织退行性疾病的患者数量正在增加。为了治疗这些疾病，本项目研究了结缔组织再生药物。它们是（1）与周围软组织连接的牙种植体（模仿Sharpey纤维），（2）骨组织表面的骨生成（人工诱导骨膜骨生长），和（3）小供血血管的封闭装置（自体骨移植技术）。各自主题的成就;（1）证实胶原纤维自体锚定在植入物表面的网状结构上，实现软组织的牢固固定，（2）结合使用羟基磷灰石/胶原纳米复合材料，实现了在骨膜下人工创造的空间中的骨生成，（3）成功研制出直径为1 mm的血管微导管。

Number of patients suffering degenerative disorder of connective tissues is increasing as the aging of populations. For the treatment of such disorders, regenerative medicines of connective tissues were investigated in this project. They were (1) dental implant connecting to surrounding soft tissues (mimics of Sharpey fibers), (2) bone generation on the surface of bone tissue (artificially induced periosteal bone growth), and (3) anastomosing devices for small feeding vessels (technology for autogenous bone grafting). Achievement for respective theme are; (1) autologous anchorage of collagen fibers onto the mesh structures placed on the surface of implants were confirmed and firm fixation of soft tissues were realized, (2) bone generation in the artificially created space under the periosteum was realized with the combined usages of hydroxiapatite/collagen nano-composites, and (3) the miniature devices developed successfully anastomose vessels as small as 1 mm diameter.