Development for medicinal chemistry on antitumor isoquinoline marine natural products as lead compound

在我们对新代谢物的研究过程中，包括生物活性化合物的分离和表征以及它们各自的同源物的制备，我们可以从蓝色海绵中分离出几种新的海洋异喹啉，如瑞尼霉素V-Y。二是成功地合成了利尼霉素G和crisstatin 4。此外，许多肾霉素左半部分的模型化合物是由苯丙氨酸衍生物制备的。天然产物及其衍生物以及合成类似物的初始细胞毒性谱也被提出。

In the course of our research on new metabolites, which involves the isolation and characterization of biologically active compounds and the preparation of their respective alnalogues, we can isolate several new marine isoquinolines, such as renieramycin V-Y from blue sponges. The second, we are succeeded to the total syntheses of renieramycin G and cribrstatin 4. Furthermore, many model compounds of the left half of renieramycins were prepared from phenylalanine derivatives. The initial cytotoxicity profiles of natural products and their derivatives along with synthetic analogues are also presented.