Elucidation of role of fatty acid-binding protein in vascular endothelial function and blood pressure control

脂肪酸结合蛋白4在脂肪细胞和巨噬细胞中均有表达，在代谢综合征的许多方面发挥重要作用。在这里，我们研究了FABP4的分泌形式和异位表达在血压调节中的作用。高血压病患者血清FABP4水平显著高于正常血压患者。血清FABP4水平与血压、胰岛素抵抗呈正相关。血管紧张素II受体阻滞剂显著降低高血压患者FABP4水平。FABP4基因缺陷的小鼠不受血压升高的影响。FABP4的表达与炎症标志物的升高有关。进一步了解FABP4在血压和内皮功能中的作用将有助于开发新的高血压治疗策略。

Fatty acid-binding protein 4 is expressed in both adipcoytes and macrophages and plays an important role in many aspects of metabolic syndrome. Here we investigated the role of secreted form and ectopic expression of FABP4 on blood pressure regulation. Serum FABP4 level was significantly higher in essential hypertensives than in normotensives. Serum FABP4 level was positively and independently correlated with blood pressure and insulin resistance. Angiotensin II receptor blockers significantly decreased FABP4 level in hypertensives. FABP4-deficient mice protected from blood pressure elevation. Expression of FABP4 was related to increased inflammatory markers. Further understanding of role of FABP4 on blood pressure and endothelial function will enable the development of new therapeutic strategies for hypertension.