Analysis of paracellular sodium ion transport in the thin ascending limb of Henle's loop

我们利用体外微灌流技术分析了哺乳动物尿液浓缩机制中起重要作用的细长升肢的细胞旁钠离子转运机制。我们检查了醛固酮和胰岛素是否影响跨上皮电压。然而，跨上皮电压保持不变。这些结果意味着它们都不影响钠离子在这一部分的运输。此外，根据一些实验，胰岛素样生长因子-1也得出了同样的结果。

We analyzed paracellular sodium ion transport mechanism in the thin ascending limb, which plays an important role in mammalian urine-concentrating mechanism, using in vitro microperfusion technique. We examined whether aldosterone and insulin affected the transepithelial voltages or not. However, the transepithelial voltages remained unchanged. These results meant that both of them did not affect a sodium ion transport in this segment. Besides, according to just a few experiments, insulin like growth factor - 1 also suggested the same result.