Development of new therapy using novel chimeric oncolytic adenoviruse vector for intractable bladder cancer.

在本研究中，我们检测了纤维结节代替腺病毒载体是否提高了对对腺病毒基因治疗结果没有显著影响的人膀胱癌的基因治疗效果。结果表明，新型纤维结节代替腺病毒载体Ad5F35/MK在体内外对人膀胱癌的基因治疗效果优于非纤维结节取代的Ad5/MK载体。

In this study, we examined whether the fiber knob substituted adenovirus vector enhance the therapeutic effect of gene therapy for human bladder cancer which do not have a significant effect on therapeutic outcome of adenovirus gene therapy. Our data showed the novel fiber knob substituted adenovirus vector, Ad5F35/MK, is more useful for the gene therapy of bladder cancer than the non fiber knob substituted Ad5/MK is for human bladder cancer in vitro and in vivo.