Establishment and application of cancer-tissue originated spheroids(CTOSs) of gynecologic cancer

对妇科癌症患者进行预先检查的药敏试验可能会有一定的价值。本研究的目的是利用CTOS（癌组织起源球体）培养手术提取的癌细胞，建立药物敏感性检查方法。结果表明，在子宫内膜癌中，浆液性腺癌衍生的CTOS制备和维持成功率高。此外，在抑制信号相关肿瘤生长的药物中，mTOR抑制剂、NF-kB抑制剂表现出中等的活性。

Drug sensitivity test for the patient of gynecology cancer by checking beforehand may give a merit. The aim of this study is establishment of a drug sensitivity examination using CTOS (cancer tissue-originated spheroid) which cultured the cancer cell extracted by an operation. As a result, it was revealed that among endometrial cancer, CTOS derived from the serous adenocarcinoma was prepared and maintained with high success rate. In addition, among the drugs which inhibit a signal related cancer growth, mTOR inhibitor, NF-kB inhibitor showed moderate activity.