Effects of intravenous anesthetics on the angiotensin II receptor of vascular smooth muscle cells

在接受血管紧张素II型1受体拮抗剂或血管紧张素转换酶抑制剂治疗的患者中，即使降压效果相同，血压也比接受钙拮抗剂治疗的患者降低。我检查了各种静脉麻醉药是否参与血管紧张素II型1受体的表达水平。发现静脉麻醉药不影响1型和2型血管紧张素受体。我认为静脉麻醉药对肾素-血管紧张素系统的影响有待进一步研究。

In patients receiving angiotensin II type 1 receptor antagonist or angiotensin converting enzyme inhibitor, blood pressure is lowered than patients receiving calcium antagonist even if the anti-hypertensive effect is the same extent.I examined whether various intravenous anesthetics is involved in the expression level of the angiotensin II type 1 receptor. It was found that intravenous anesthetics was not affect the type 1 nor type 2 angiotensin II receptors. I considered that it is necessary to further study in the future about the effects of intravenous anesthetics on the renin-angiotensin system.