Research in the interaction of dopaminergic functions in the basal ganglia

中枢多巴胺（DA）系统在大脑组织行为和各种疾病中起着关键作用。研究结果表明，刺激伏隔壳区多巴胺D_1/2受体可通过直接或间接的前反馈回路减少背纹状体多巴胺外排，该反馈回路涉及壳、核、腹外侧纹状体和背纹状体：壳区多巴胺D_1/2受体可减少核心区多巴胺外排；核心区D_1/2受体的抑制增加了上下丘脑的多巴胺外排，而上下丘脑D_1/2受体的刺激减少了下丘脑的多巴胺外排。最后，刺激壳内D_1/2受体可减少DS内DA的外排。因此，我们提供证据支持螺旋纹状体-黑质纹状体连接的存在。

Central dopamine (DA) systems are key players in the cerebral organization of behavior and various diseases. We show that stimulation of DA D_1/2 receptors in the accumbal shell decreased dorsal striatal DA efflux via a direct or indirect feed-forward loop involving shell, core, ventrolateral striatum (VLS) and dorsal striatum (DS): stimulation of D_1/2 receptors in the shell decreased DA efflux in the core; inhibition ofD_1/2 receptors in the core increased DA efflux in the VLS, and stimulation of D_1/2 receptors in the VLS decreased DA efflux in the DS. Finally, stimulation of D_1/2 receptors in the shell decreased DA efflux in the DS. Thus, we provide evidence in favor of the existence ofspiraling striato-nigro-striatal connections.