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Roles of the prostanoids in the regulation of immunological responses

Roles of the prostanoids in the regulation of immunological responses
前列腺素在免疫反应调节中的作用
批准号:
23659130
负责人:
USHIKUBI Fumitaka
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
为了阐明前列腺素在免疫反应调节中的作用,我们采用了两个依赖于免疫反应的病理生理学的动物模型:肾间质纤维化和刀豆蛋白A诱导的肝炎。通过对这些动物模型的分析,我们发现了PGE2-Ep4系统在肾间质纤维化和ConA诱导的肝炎中的新的作用和作用机制。
英文摘要
To clarify the roles of the prostanoids in the regulation of immunological responses, we employed two animal models showing pathophysiology dependent on immunological responses; renal interstitial fibrosis and Con A-induced hepatitis. Through the analysis of these animal models, we found novel roles and action mechanisms of the PGE2-EP4 system in the development of renal interstitial fibrosis and Con A-induced hepatitis._4
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会议论文
Roles of prostanoids in the pathogenesis of cardiovascular system: Novel insights from knockout mouse studies
前列腺素类药物在心血管系统发病机制中的作用:基因敲除小鼠研究的新见解
DOI: --
发表时间: 2011
期刊: Pharmacol Ther
影响因子: --
作者: [Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al]
通讯作者: et al
DOI: 10.1007/s00535-012-0718-5
发表时间: 2013-08
期刊: Journal of Gastroenterology
影响因子: 6.3
作者: [Md. Rafiqul Islam Khan;A. Anisuzzaman;S. Semba;Yanju Ma;Junsuke Uwada;H. Hayashi;Yuichi Suzuki;T. Takano;H. Ikeuchi;M. Uchino;A. Maemoto;F. Ushikubi;I. Muramatsu;T. Taniguchi]
通讯作者: Md. Rafiqul Islam Khan;A. Anisuzzaman;S. Semba;Yanju Ma;Junsuke Uwada;H. Hayashi;Yuichi Suzuki;T. Takano;H. Ikeuchi;M. Uchino;A. Maemoto;F. Ushikubi;I. Muramatsu;T. Taniguchi
Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning
  • 批准号:
    25670124
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.5万
  • 财政年份:
    2013
  • 负责人:
    USHIKUBI Fumitaka
  • 依托单位:
Roles of the prostanoids in the pathogenesis of cardiovascular diseases
  • 批准号:
    22390045
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.9万
  • 财政年份:
    2010
  • 负责人:
    USHIKUBI Fumitaka
  • 依托单位:
Roles of prostanoids in the pathogenesis of cardiovascular diseases
  • 批准号:
    19390060
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.81万
  • 财政年份:
    2007
  • 负责人:
    USHIKUBI Fumitaka
  • 依托单位:
Roles of prostanoids in cardiovascular system revealed from studies using knockout mice
  • 批准号:
    14370049
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $9.41万
  • 财政年份:
    2002
  • 负责人:
    USHIKUBI Fumitaka
  • 依托单位:
海外基金