Roles of versican in development and maintenance of hair follicles

Versican （Vcan）是细胞外基质的一种大型硫酸软骨素蛋白多糖，它在软骨原基和真皮乳头等间质凝聚区短暂表达。在这里，我们的目的是研究Vcan在毛囊发育和维持中的作用。虽然我们在Vcan<flox/flox>小鼠皮内注射了表达cre的腺病毒，但我们不能消除其在真皮乳头细胞中的表达。目前，我们正计划生成Corin-cre；Vcan<flox/flox>小鼠，在真皮乳头中缺乏Vcan表达。

Versican (Vcan) is a large chondroitin sulfate proteoglycan of the extracellular matrix, which is transiently expressed in mesenchymal condensation areas such as cartilage primordium and dermal papilla. Here, we aimed to investigate the role of Vcan in development and maintenance of hair follicles. Though we performed intradermal injection of adenovirus expressing cre into Vcan<flox/flox> mice, we could not ablate its expression in dermal papilla cells. Currently, we are planning to generate Corin-cre; Vcan<flox/flox> mice, which lack Vcan expression in dermal papillae.