Structural studies of plant disease resistance proteins

植物细胞已经进化出一种基因对基因的抗病机制，涉及植物源性受体与特定病原体源性分子的相互作用。目前，植物育种者仅限于在特定作物品种或性亲和性亲缘中可用的抗性基因。近年来，一些植物抗病基因被鉴定出来，为研究植物抗病过程的分子基础奠定了基础。我们建议获得代表性R蛋白及其配体复合物的三维结构信息。这将构成修改现有抗性基因以赋予对新疾病的抗性的基础，从而产生巨大的经济效益。

Plant cells have evolved a gene-for-gene disease resistance mechanism, involving an interaction of a plant-derived receptor with a specific pathogen-derived molecule. Currently, plant breeders are restricted to the resistance genes available in particular crop species or sexually compatible relatives. In the last few years, several plant disease resistance genes have been identified, providing a foundation for studying the molecular basis of the resistance process. We propose to obtain three-dimensional structural information on representative R proteins and their ligand complexes. This will form the basis for modifying existing resistance genes to confer resistance to new diseases, resulting in large economic benefits.