The elucidation of the effect of T-cell and mechanism of metabolic syndrome by dietary composition

代谢综合征是进行危重疾病、糖尿病、中风等的基础疾病。近几年的研究表明，T细胞在脂肪组织中的渗透调节了巨噬细胞的分化，从而导致了脂肪组织和全身的慢性炎症。我们曾报道过大豆异黄酮的免疫功能。本研究通过观察大豆异黄酮对饮食诱导肥胖小鼠炎症反应的影响，发现大豆异黄酮能改善糖代谢和脂代谢，减少体内脂肪的积累。特别是，Equol显著抑制了基因相关巨噬细胞的表达。因此，大豆异黄酮可望预防代谢综合征。

Metabolic syndrome is the underlying disease proceed crirical disorder, diabetes, stroke, et al. Nearly, it was reported that T cell-infiltrated in adipose tissues was regulated differentiation of macrophage, so macrophage was dictated chronic inflammation in adipose tissue and whole-body. We ever reported about immune function of soy isoflavone. In this study, we examined effect of Soy isoflavones on the inflammation in diet indused obesity mice.Soy isoflavones were ameliorated glucose metabolism and lipid metabolism, and declining trend to accumulation of body fat. In particular, Equol was significantly inhibited expression of gene associated macrophage. Thus, it is suggested that soy isoflavone might be possible to prevent metabolic syndrome.