Analysis of mechamisms in brain tumor stem cell regulation by polyphenol

白藜芦醇（RSV）是一种天然的多酚化合物，存在于植物和由植物制成的食物中，可以穿过血脑屏障。胶质母细胞瘤（GBM）是恶性程度最高的原发性脑肿瘤，已知含有肿瘤干细胞（CSCs）。CSCs似乎是GBM对各种疗法（如化学制剂或辐射）产生强大抵抗力的重要原因。本研究提示RSV对GBM （U87细胞）CSCs的抗肿瘤作用及其Sirtuin （SIRT）基因等机制。形态学变化和表达蛋白分析结果表明：(1)RSV可诱导GBM- csc分化，使GBM对治疗反应更强；(2) RSV对GBM的抗肿瘤作用可能与SIRT基因（SIRT 1、2、3、6）的激活或失活有关，SIRT基因可诱导CSC分化，减少恶性肿瘤，减少细胞死亡。

Resveratrol (RSV) is a natural polyphenolic compound, present in plants and food made from plants, that can cross the blood-brain barrier. Glioblastoma (GBM) is the most malignant primary brain tumor, which is known to have cancer stem cells (CSCs). CSCs appear to be an important cause of GBM's formidable resistance to various therapies, such as chemical agents or radiation.In the present study, RSV's anti-tumor effects against CSCs in GBM (U87 cells) and mechanisms including Sirtuin (SIRT) genes were indicated. The results from analyses of morphological changes and expressed proteins indicated: (1) RSV can induce GBM-CSC differentiation, which could make GBM more responsive to therapies; (2) RSV's anti-tumor effects on GBM may include mechanisms related to the activation or inactivation of SIRT genes (SIRT 1, 2, 3, 6) that induce CSC differentiation, which contribute to reduction of the malignancy, and cell death.