糖尿病性心筋症に対するＤＰＰ－４阻害剤の役割検討

2型糖尿病（T2 DM）使患有和不患有心血管疾病的患者发生主要心血管并发症的风险加倍，因此大多数糖尿病患者死于心血管疾病。迄今为止，大多数报告的评价特定降糖策略或药物对心血管结局影响的试验要么效力不足，要么未显示出显著的心血管获益或死亡或心力衰竭风险增加。因此，我们计划研究IL-33在机械超负荷后心力衰竭小鼠中左心室重塑事件的调节中的作用，因为已经报道IL-33在小鼠肥胖期间诱导脂肪组织炎症的保护作用（米勒AM等人，2010年）。超声心动图检测左室舒张末期内径（LVDd）、左室收缩期内径（LVSd）、室间隔内径（IVSd）、左室后壁厚度（LVPWd）及左室短轴缩短率（% FS）。与基线相比，在TAC手术后8周，WT和IL-33-/-小鼠中均观察到心脏功能受损，表现为LVDd、LVSd、IVSd和LVPWd增加以及%FS降低。IL-33-/-小鼠中的这些参数与其WT-同窝小鼠相比有所改善。

Type 2 diabetes mellitus (T2DM) doubles the risk of major cardiovascular complications in patients with and without established cardiovascular disease, such that the majority of patients with diabetes die of cardiovascular diseases. Most of reported trials to date evaluating the effects on cardiovascular outcomes of specific glucose-lowering strategies or medications either have been insufficiently powered or have shown no significant cardiovascular benefit or an increased risk of death or heart failure. Hence, we plan to investigate the role of IL-33 in the modulation of left ventricular remodeling events in mice with heart failure following mechanical overload, since it has been reported that IL-33 induces protective effects in adipose tissue inflammation during obesity in mice (Miller AM et al., 2010). Myocardial functional parameters such as left ventricular dimension in diastole (LVDd) and systole (LVSd), intra ventricular septal diameter (IVSd) and posterior wall thickness (LVPWd) and fractional shortening (% FS) were assessed by echocardiography. Impaired cardiac function were noted in both in WT and IL-33-/- mice followed 8-weeks after TAC operation when compared to baseline, as evidenced by increased LVDd, LVSd, IVSd and LVPWd and reduced %FS. These parameters in IL-33-/- mice were improved compared with those in their WT-littermates.