Tracking nanoparticles: from cell culture to in vivo delivery

在细胞生物学的新时代，理解细胞如何在活的有机体的“实时”环境中发挥作用是一个关键的挑战。使用超分辨率光学显微镜和最先进的相关电子显微镜以及模型系统，该奖学金旨在提供对细胞在自然环境中的新理解。值得注意的是，该项目将阐明蛋白质或纳米颗粒如何从血流进入组织，然后进入细胞，并在这样做的过程中提供亟需的蛋白质和颗粒原位运输的知识。成果和好处包括前沿基础科学对细胞功能的研究、教育、推广以及澳大利亚在高需求技能方面的能力建设。

Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodstream into tissues and then into cells, and in doing so deliver much-needed knowledge of protein and particle trafficking in situ. Outcomes and benefits include leading-edge fundamental science into the function of cells, education, outreach and building of Australian capacity in high-demand skill sets.