Development of Chinese Lemming as an Experimental Animal

对1998 ~ 1999年2年间在新疆维吾尔自治区捕获的野生鼠类进行了寄生虫学和病毒学调查。为了开发新人类传染病的实验动物模型,试图后方Lagurus Lagurus和梅里恩meridianus在实验室和实验感染laboratory-born动物棘球绦虫spp。婴儿利什曼虫和隐孢子虫spp.A共有569只野生小动物被捕获在17个地区及周边地区太天山和阿尔泰山和2属于家庭,2属2种食虫类,和3家庭,18个属,啮齿类动物25种。经寄生虫学检查，捕获动物共检出棘头类和线虫24种，绦虫7种。20匹马中有4匹检测到抗博纳病毒抗体，20只羊中有5只检测到抗博纳病毒抗体。在豚鼠、子午棘球绦虫和金仓鼠棘球绦虫感染实验中，子午棘球绦虫对多房棘球绦虫和细粒棘球绦虫感染均高度敏感。在经口接种隐孢子虫2 ~ 18 d的lagurus和m.a meridianus的粪便中均检测到紫隐孢子虫和C.muris的卵囊，表明这两种动物可作为隐孢子虫病的新感染模型。实验感染婴儿乳杆菌时，原虫在大鼠肝脏和脾脏的生长速度比在仓鼠肝脏和脾脏的生长速度快。

Parasitological and virological surveys of wil rodents captured in the Xinjiang-Uygur autonomous region of China over 2 years from 1998 through 1999 were carried out. In order to develop new laboratory animal models for human infectious diseases, attempts were made to rear Lagurus lagurus and Meriones meridianus in the laboratory and to experimentally infect the laboratory-born animals with Echinococcus spp., Leishmania infantum and Cryptosporidium spp.A total of 569 wild small animals were captured in 17 localities in and around Mt. Tien-Shan and Mt. Altai and belonged to 2 families, 2 genera and 2 species of Insectivora, and 3 families, 18 genera, and 25 species of Rodentia. Twenty four species of acanthocephala and nematodes, and seven species of cestodes were obtained from the captured animals in parasitological examinations. Anti-Borna disease virus antibodies were detected in 4 out of 20 horses and 5 out of 20 sheep.In experimental infection of L.lagurus, M.meridianus and golden hamster with Echinococcus spp, M.meridianus was highly sensitive to both E.multilocularis and E.granulosus infections. Oocysts of Cryptosporidum purvum and C.muris were detected in feces from both L.lagurus and M.meridianus orally inoculated with Cryptosporidum spp. for 2 to 18 days after inoculation, indicating that these animals can be used as a new infection model for cryptosporidiosis. In experimental infection with L.infantum, the protozoa grew more rapidly in livers and spleens of L.lagurus than in those of hamsters.