Activity-based chemogenetics: a novel approach to modulating brain function

目的：通过开发一种全新的方法来解开脊椎动物大脑令人震惊的复杂性，这种方法能够操纵特定神经细胞的活动来研究行为。意义：这些技术进步对于理解大脑的复杂功能至关重要。预期成果：我们将提供广泛的技术进步，这将导致世界各地的新神经科学。我们还将通过计划验证我们的工具的实验来增加对体重控制的理解。优点：我们的技术进步有可能改变实验方案，以及实验神经科学在试图了解大脑功能的所有领域获得的信息。

Aim: To unravel the astounding complexity of the vertebrate brain by developing a completely novel method, that enables manipulation of the activity of defined nerve cells to study behaviour. Significance: Such technical advances are essential for understanding the intricate function of the brain. Expected outcomes: We will provide a technical advance of broad scope that will lead to novel neuroscience throughout the world. We will also increase understanding of body weight control through the experiments planned to validate our tool. Benefit: Our technical advance has the potential to alter experimental protocols, and the information obtained by experimental neuroscience, across all areas attempting to understand brain function.