Leveraging Bio-Cultural Mechanisms to Maximize the Impact of Multi-Level Preventable Disease Interventions with Southwest Populations

利用生物文化机制增加多层次的影响 西南地区人群可预防疾病干预措施 项目摘要/摘要 拟建的U54专业中心将增进有关如何预防心脏代谢性疾病和 西南部健康差距人群中的药物滥用障碍。西南地区 在过去的10年里，跨学科研究中心(SIRC)在这一领域积累了宝贵的专业知识 作为亚利桑那州立大学的卓越探索中心(NIMHD/NIH P20MD002316)。赤裸裸的未得到满足的健康需求 在西南社区，为这项应用而聚集的强大的跨学科研究团队， 现有的坚实的社区合作伙伴关系使这一应用程序具有非常重要的意义。专门化中心 将利用SIRC在健康和健康的文化和社会决定因素方面积累的知识 并将把生物、社会文化和其他背景因素纳入有效的、文化的 扎实有效的卫生干预措施。我们将重点了解以下方面的保护和风险影响 人际关系、家庭与家庭因素、社区环境与个体健康行为 具体的生物健康结果。专业中心将扩展SIRC的综合、多层次、社会 将生物文化机制纳入生态发展理论框架的决定因素方法。这个 拟议的中心将通过专注于预防的研究来显著增强SIRC的研究影响力 心脏代谢性疾病和物质滥用障碍通过文化上的适当和有效 干预措施。这项拟议的研究具有创新性，因为它将调查保护性因素和风险因素如何 在种族/少数民族中表现为各种慢性病和障碍的常见疾病 西南部人口，重点是健康的社会文化和生物决定因素 差距。拟议的两个主要研究项目将针对潜在的可改变的青少年行为 与心脏代谢性疾病和物质滥用障碍有关(即，体力活动和质量 关于饮食、获得健康食品、家庭功能、文化适应、物质使用和非法药物供应的问题)。 由此产生的发现将为设计和测试有效的干预措施提供信息，这些干预措施可以加强 在幼鱼的多个生态域内运行的保护因素和抵消风险因素 人的生命。该中心将开展两个相关的主要研究项目，以增加对 通过促进关于文化过程如何影响生物脆弱性的知识进行有效的干预 (即，生物文化机制)。早期职业教师和博士后将提高他们指导健康的能力 通过全面的调查员开发和试点研究孵化器倡议来划分研究。 该中心将在密切和公平的伙伴关系中实施研究项目和未来的试点 西南部的社区。该中心将与SIRC社区咨询委员会合作， 广泛传播研究和试点产生的知识，并将其转化为政策、实践和 通过创新的传播计划吸引利益相关者。

Leveraging Biocultural Mechanisms to Increase the Impact of Multi-level Preventable Disease Interventions with Southwest Populations Project Summary/Abstract The proposed U54 Specialized Center will advance knowledge on how to prevent cardiometabolic disease and substance abuse disorders among the health disparities populations of the Southwest. The Southwest Interdisciplinary Research Center (SIRC) has accumulated invaluable expertise in this area for the past 10 years as ASU's Exploratory Center of Excellence (NIMHD/NIH P20MD002316). The stark unmet health needs of the Southwest communities, the strong transdisciplinary team of researchers assembled for this application, and the existing solid community partnerships make this application highly significant. The Specialized Center will leverage SIRC's accumulated knowledge on cultural and social determinants of health and health disparities and will integrate biological, sociocultural and other contextual factors into efficacious, culturally grounded and impactful health interventions. We will focus on understanding the protective and risk effects of interpersonal family and household factors, the community environment, and individual health behaviors on specific biological health outcomes. The Specialized Center will extend SIRC's integrated, multilevel, social determinants approach to include biocultural mechanisms within an Ecodevelopmental Theory framework. The proposed center will significantly enhance SIRC's research impact through a research focus on preventing cardio metabolic disease and substance abuse disorders through culturally appropriate and efficacious interventions. The proposed research is innovative because it will investigate how protective and risk factors that are common to various chronic diseases and disorders manifest themselves among racial/ethnic minority populations of the Southwest, with an emphasis on the sociocultural and biological determinants of health disparities. The two proposed main research projects will target potentially modifiable youth behaviors associated with cardiometabolic disease and with substance abuse disorders (i.e., physical activity, and quality of diet, access to healthy foods, family functioning, acculturation, substance use, and illegal drug availability). The resulting findings will inform the design and testing of efficacious interventions that can strengthen protective factors and counteract risk factors operating within the multiple ecological domains of a young person's life. The center will conduct the two related main research projects to increase the impact of efficacious interventions by advancing knowledge on how cultural processes influence biological vulnerabilities (i.e., biocultural mechanisms). Early career faculty and postdocs will increase their capacity to conduct health dipartites research through a comprehensive investigator development and pilots research incubator initiative. The center will implement the research projects and future pilots in close and equitable partnership with communities of the Southwest. In partnership with the SIRC Community Advisory Board, the center will broadly disseminate and translate the knowledge generated by the studies and pilots to policy, practice, and lay stakeholders through an innovative dissemination plan.