National Xenopus Resource Center
National Xenopus Resource Center
批准号:
10155610
负责人:
Marko E Horb
金额:
$6.61万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
未结题
起止时间:
2010-08-12 至 2025-04-30
关键词:
Animal HousingAnimalsApplied ResearchBioinformaticsCodeCommunitiesCustomDNA Sequence AlterationEducational workshopEnsureGenesGrantImageIndividualInstitutesLightMapsMethodsMusMutationReproducibilityResearchResearch PersonnelResourcesSalesServicesSiteTechnologyTransgenesTransgenic MiceTransgenic OrganismsUnited States National Institutes of HealthWorkXenBaseXenopusgenome editingintegration sitemeetingsmutantrepositoryresearch facility
中文摘要
项目摘要-项目组成部分
项目部分概述了国家非洲爪哇资源(NXR)的应用研究。转基因
线路是NXR的最大单一组件。这些生产线对于各个实验室及其销售是必不可少的
每年都在增加。近年来,有研究表明,在大多数小鼠转基因品系中都有
转基因整合部位及其周围的基因组改变。这些变化可能会影响
内源基因的表达,甚至导致这些基因的突变。因此,至关重要的是,我们
确定我们转基因品系的整合位点。在此组件中,我们概述了将采取的步骤以确定
我们的五个转基因品系的整合地点。
英文摘要
Project Summary – Project Component
The Project Component outlines the applied research of the National Xenopus Resource (NXR). Transgenic
lines are the single largest component of the NXR. These lines are essential for individual labs and their sales
are increasing each year. In recent years, it has been shown that in most mouse transgenic lines there are
genomic alterations in and around the integration sites of transgenes. These changes can influence the
expression of endogenous genes or even cause mutations in these genes. Therefore, it is essential that we
define the integration sites for our transgenic lines. In this Component we outline the steps we will take to identify
the integration sites for five of our transgenic lines.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
XenCAT: Xenopus Single Cell Atlas
-
批准号:10669806
-
项目类别:
-
资助金额:$79.28万
-
财政年份:2022
-
负责人:Marko E Horb
-
依托单位:
XenCAT: Xenopus Single Cell Atlas
-
批准号:10807246
-
项目类别:
-
资助金额:$24.88万
-
财政年份:2022
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10206289
-
项目类别:
-
资助金额:$77.68万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10644188
-
项目类别:
-
资助金额:$16.09万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10047403
-
项目类别:
-
资助金额:$79.36万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10435421
-
项目类别:
-
资助金额:$75.8万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10455298
-
项目类别:
-
资助金额:$22.94万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10646475
-
项目类别:
-
资助金额:$74.01万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Xenopus Mutant Resource
-
批准号:10807617
-
项目类别:
-
资助金额:$23.62万
-
财政年份:2020
-
负责人:Marko E Horb
-
依托单位:
Enhancing CRISPR-Cas for disease modeling in Xenopus
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批准号:9900078
-
项目类别:
-
资助金额:$20.75万
-
财政年份:2019
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负责人:Marko E Horb
-
依托单位:
Xenopus models of human disease by targeted genome editing
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批准号:9257431
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项目类别:
-
资助金额:$58.31万
-
财政年份:2015
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10155609
-
项目类别:
-
资助金额:$63.16万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10155608
-
项目类别:
-
资助金额:$69.77万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10394273
-
项目类别:
-
资助金额:$61.35万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10621146
-
项目类别:
-
资助金额:$59.48万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10609622
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项目类别:
-
资助金额:$28.57万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10621151
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项目类别:
-
资助金额:$6.61万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10394274
-
项目类别:
-
资助金额:$6.61万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10661157
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项目类别:
-
资助金额:$28.57万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
National Xenopus Resource Center
-
批准号:10405208
-
项目类别:
-
资助金额:$20.12万
-
财政年份:2010
-
负责人:Marko E Horb
-
依托单位:
海外基金