Xenopus Mutant Resource

非洲爪蟾突变体资源

• 批准号: 10807617
• 负责人: Marko E Horb
• 金额: $ 23.62万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10807617
• 关键词: Administrative Supplement; Adult; Amphibia; Animals; Biological; Biomedical Research; Blood capillaries; Cellular biology; Data; Destinations; Development; Dideoxy Chain Termination DNA Sequencing; Disease; Embryo; Equipment; Faculty; Funding; Gene Expression; Genes; Genotype; Grant; Growth; Laboratories; Molecular; Mutation; Nature; Neurobiology; Phenotype; Physiology; Postdoctoral Fellow; Process; R24; Rana; Reaction; Research; Research Personnel; Resources; Running; Sampling; Scientist; Signal Transduction; System; Tadpoles; Temperature; Time; Tissue Sample; Training; Transgenic Organisms; Visit; Work; Xenopus; Xenopus laevis; cost; graduate student; human disease; human model; insight; marine; mutant; new technology; success; targeted sequencing

Project Summary The Xenopus Mutant Resource (XMR) was created in 2020 as an R24 resource center at the National Xenopus Resource (NXR) at the Marine Biological Laboratory in Woods Hole, MA. The purpose of the XMR is to create new mutant and transgenic lines in both Xenopus laevis and Xenopus tropicalis and to provide a destination for researchers to come and work on these various lines. An essential component of the XMR is the ability to host visiting scientists. This grant supports a project to purchase additional equipment that will allow us to more efficiently genotype our animals and be able to quantitatively examine gene expression changes.

项目摘要 非洲爪哇突变资源(XMR)创建于2020年，是国家科学研究院的R24资源中心 马萨诸塞州伍兹霍尔海洋生物实验室的非洲爪哇资源(NXR)。XMR的目的是 在非洲爪哇和热带非洲爪哇建立新的突变和转基因品系，并提供 研究人员来这些不同的线路工作的目的地。XMR的一个基本组件是 接待来访科学家的能力。这笔赠款支持一个购买额外设备的项目，该设备将 使我们能够更有效地对我们的动物进行基因分型，并能够定量检测基因表达 改变。

项目成果

Age-associated DNA methylation changes in Xenopus frogs.

• DOI: 10.1080/15592294.2023.2201517
• 发表时间: 2023-12
• 期刊: EPIGENETICS
• 影响因子: 3.7
• 作者: Morselli, Marco;Bennett, Ronan;Shaidani, Nikko-Ideen;Horb, Marko;Peshkin, Leonid;Pellegrini, Matteo
• 通讯作者: Pellegrini, Matteo

TGF-β1 signaling is essential for tissue regeneration in the Xenopus tadpole tail.

• DOI: 10.1016/j.bbrc.2021.05.082
• 发表时间: 2021-08-06
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Nakamura M;Yoshida H;Moriyama Y;Kawakita I;Wlizla M;Takebayashi-Suzuki K;Horb ME;Suzuki A
• 通讯作者: Suzuki A

Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease.

• DOI: 10.1002/dvg.23453
• 发表时间: 2021-12
• 期刊: Genesis (New York, N.Y. : 2000)
• 作者: Coppenrath K;Tavares ALP;Shaidani NI;Wlizla M;Moody SA;Horb M
• 通讯作者: Horb M

Normal Table of Xenopus development: a new graphical resource.

• DOI: 10.1242/dev.200356
• 发表时间: 2022-07-15
• 期刊: Development (Cambridge, England)

Deep learning is widely applicable to phenotyping embryonic development and disease.

• DOI: 10.1242/dev.199664
• 发表时间: 2021-11-01
• 期刊: Development (Cambridge, England)
• 作者: Naert T;Çiçek Ö;Ogar P;Bürgi M;Shaidani NI;Kaminski MM;Xu Y;Grand K;Vujanovic M;Prata D;Hildebrandt F;Brox T;Ronneberger O;Voigt FF;Helmchen F;Loffing J;Horb ME;Willsey HR;Lienkamp SS
• 通讯作者: Lienkamp SS