Cardiorenal and Metabolic Diseases Research Center

总体来说 项目摘要/摘要 心血管疾病、肾脏疾病和代谢性疾病有着千丝万缕的联系，是导致 美国的死亡率和发病率，特别是在密西西比州，密西西比州是全国发病率最高的州 这些疾病。心肾功能紊乱和代谢紊乱通常聚集在一起，高度相互依存。 肥胖和相关的代谢紊乱，如糖尿病，是心血管疾病和肾脏疾病的主要原因。 肾功能异常是高血压的重要原因和后果，高血压是高血压的关键危险因素 心血管疾病，如冠状动脉疾病和中风。了解简历之间的复杂关系， 肾脏、代谢障碍和开发新的治疗方法需要在 融合了多学科综合方法的研究，结合了基础、临床和 人口学家。此第二阶段Cobre提案的一个主要目标是进一步发展领先的 心肾和代谢性疾病研究中心(CMDRC)汇集了一个多学科小组 基础、临床和人口科学家致力于一个共同的协同主题，并促进他们的 合作。具体目标是：1)进一步发展基础设施和核心设施，以促进 在心肾和代谢性疾病的基础、临床和人群研究方面的卓越表现，并增加 CMDRC研究人员对NIH和其他国家生物医学机构独立资助的竞争力 研究计划；2)加强CMDRC的指导和教育计划以及研究支持 承诺新的调查人员，这样他们就可以成为富有成效的独立调查人员，他们也是 多学科研究团队的有效协作者；3)实现研究的具体目标 初级调查员在本建议中描述的项目，并促进他们的职业发展；4)进一步 培养不同的博士后研究员、受过切割培训的研究生和本科生 心肾和代谢性疾病研究的前沿，因此他们成为这方面的下一代研究人员 外地；主要重点是通过以下途径招聘和指导任职人数不足的少数族裔调查员 与当地机构建立伙伴关系，并利用UMMC的培训方案；5)加强合作 以及来自多个学科的现有研究人员在心肾和代谢方面的互动 UMMC的疾病，其他IDEA支持的计划，以及外部合作伙伴；6)加强心肾和 通过招聘具有临床和翻译专业知识的新教员来UMMC进行代谢性疾病研究 研究，以及新兴技术(例如活体成像、生物信息学和系统分析)和 在CMDRC专业知识方面存在差距的领域。

OVERALL PROJECT SUMMARY/ABSTRACT Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of CV and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for CV diseases such coronary artery disease and stroke. Understanding the complex relationships among CV, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this Phase 2 COBRE proposal is to further develop a leading Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims are: 1) to further develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of CMDRC investigators for independent funding from NIH and other national biomedical research programs; 2) to enhance CMDRC mentoring and education programs and research support for promising new investigators so that they can become productive, independent investigators who are also effective collaborators on multidisciplinary research teams; 3) to achieve the specific aims of the research projects described by Junior Investigators in this proposal, and to foster their career development; 4) to further develop a pipeline of diverse postdoctoral fellows, graduate and undergraduate students trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis is placed on recruiting and mentoring underrepresented minority investigators through partnerships with local institutions and by leveraging training programs at UMMC; 5) to enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, other IDeA supported programs, and external partners; 6) to strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research, and in emerging technologies (e.g. in vivo imaging, bioinformatics, and systems analysis) and in areas where there are gaps in CMDRC expertise.