Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

项目概要（UH 3） 环境对波多黎各儿童健康结果的影响（ECHO‐PRO）项目利用了 波多黎各的一个活跃出生队列（CRINT队列）已启动儿童随访（CRECE队列） 更好地了解环境暴露及其对出生结果和儿童健康的影响 在波多黎各--一个服务不足，高度暴露的人口。“探索波多黎各试验场 污染威胁（Contamination Threats，简称CBT）是NIEHS超级基金研究计划（Superfund Research Program，简称SRP）的一个队列， 2011年招募，并将持续到2019年（P42 ES 017198）。CBT检验了以下假设： 暴露于邻苯二甲酸盐和氯化挥发性有机化合物（CVOCs）有助于 波多黎各早产率异常高（妊娠期<37周）。“研究中心” 波多黎各儿童早期接触和发展研究中心，”儿童环境健康 中心（CEHC），由NIEHS和环境保护局（EPA）于2015年联合授予 （P50 ES 026049），随访在CPDT队列中出生的儿童。CRECE正在研究 接触颗粒物和酚类物质以及改变因素对身体、生殖和 北方波多黎各儿童的神经发育。ECHO‐PRO将利用 BACT/CRECE队列（出生时570名儿童）和基础设施，并招募额外的1100名儿童 孕妇（UG 3中100例，UH 3中1000例）及其子女（出生时估计N=990） 收集ECHO范围内批准的要素进行随访评估，重复关于其 环境暴露，中间效应的生物标志物，以及呼吸，身体，生殖， 和大脑发育。

Project Summary (UH3) The Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO‐PRO) project leverages an active birth cohort in Puerto Rico (PROTECT cohort) that has initiated child follow‐up (CRECE cohort) to better understand environmental exposures and their effects on birth outcomes and children's health in Puerto Rico – an underserved, highly exposed population. “Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)” is an NIEHS Superfund Research Program (SRP) cohort that started recruiting in 2011 and will continue through 2019 (P42ES017198). PROTECT tests the hypothesis that exposure to phthalates and chlorinated volatile organic compounds (CVOCs) contributes to the unusually high rate of preterm birth (<37 weeks gestation) in Puerto Rico. The “Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE),” a Children's Environmental Health Center (CEHC), awarded jointly by NIEHS and the Environmental Protection Agency (EPA) in 2015 (P50ES026049), follows up on children born in the PROTECT cohort. CRECE is studying the impact of exposures to particulate matter and phenols and modifying factors on physical, reproductive and neurodevelopment among children in northern Puerto Rico. ECHO‐PRO will leverage the PROTECT/CRECE cohort (570 children at birth) and infrastructure, and recruit an additional 1100 pregnant women (100 in the UG3 and 1000 in the UH3) and their children (estimated N=990 at birth) collecting ECHO‐Wide approved elements for follow‐up assessments, repeated information on their environmental exposures, biomarkers of intermediate effect, and respiratory, physical, reproductive, and brain development.