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Functional And Phenotypic Characterization Of T Cells In Man

Functional And Phenotypic Characterization Of T Cells In Man
人类 T 细胞的功能和表型特征
批准号：
10275371
负责人：
Mario Roederer
金额：
$78.28万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10275371
关键词：
AdultB-LymphocytesBaltimoreCell physiologyCellsCollectionColorCryopreservationCytometryDiseaseDizygotic TwinsGeneticGoalsImmune systemLondonLymphocyte SubsetMonozygotic twinsMyeloid CellsPathogenesisPhenotypeRegulationSamplingStainsT-LymphocyteTestingVirusmanpathogen

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中文摘要
翻译
我们已经开发了一个系统化的管道，以尽可能详细地分析免疫系统。这包括每周制备100个冷冻保存的PBM种子样品的能力，然后通过细胞计数染色和收集以计数不同的样品。我们已经开发了三种不同的30色面板来区分T细胞，B细胞，骨髓细胞等，以及对它们进行功能测试。我们还将包括识别病毒特异性细胞的探针，以识别遗传学和B细胞对某些病毒的表达调控。
英文摘要
We have developed a systematic pipeline to analyze the immune system in the greatest detail possible to date. This includes the ability to prepare several 100 samples of cryopreserved PBM see every week, followed by staining and collection by cytometry to enumerate the different samples. We have developed three different 30 color panels to distinguish T cells, B cells, myeloid cells, etc., as well as to do a functional test on them. We'll also include probes that identify virus specific cells to identify the genetics and regulation of the representation of B cells against certain viruses.
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