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Identification of HIV-specific B cells in blood

Identification of HIV-specific B cells in blood
血液中 HIV 特异性 B 细胞的鉴定
批准号：
8556112
负责人：
Mario Roederer
金额：
$55.08万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8556112
关键词：
AntibodiesAntigensB-LymphocytesBindingBloodCellsFlow CytometryGoalsHIVHIV InfectionsHIV envelope proteinImmune systemIn VitroMapsMonoclonal AntibodiesMutateProtein RegionProteinsRegimenResearchTechniquesVaccinationVaccinesViral Proteinsinhibiting antibodyinterestmucosal sitepathogenresponse

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中文摘要
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英文摘要
We are using sophisticated flow cytometric techniques to characterize, in detail, the B cell responses to HIV infection and to HIV vaccination. Our goal is to identify the antigen-specific B cells, isolate them, and then map the responses of the B cells to the viral proteins. Specifically, we use fluorescently-conjugated antigens (for example, the HIV envelope protein), to identify cells which bind those proteins. By using mutated forms of the antigens, we can selectively isolate cells which bind only certain regions of the protein of interest. We hope to use this to identify antibodies (and B cells producing them) that selectively bind important regions of the HIV envelope, such as the CD4-binding domain.
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Functional And Phenotypic Characterization Of T Cells In
Develop Of Flow Cytometric Technologies For Immune Assay
Identification of HIV-specific B cells in blood
Development Of Flow Cytometric Technologies For Immune Assays
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海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
  • 批准号：
    2022J011295
  • 项目类别：
    省市级项目
  • 资助金额：
    10.0万元
  • 批准年份：
    2022
  • 负责人：
    王亚伟
  • 依托单位：
    福州市科学技术局
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究