The colour of cellular aging: a deep probe of cellular processes

理解我们为什么会衰老以及衰老是否可以预防是一项重大的研究挑战，必须首先在细胞水平上加以解决。基于我们在非侵入性细胞功能颜色监测方面的进展，该项目旨在揭示细胞过程与细胞衰老之间的密切联系，这些细胞必须存活数十年，如卵母细胞和神经元。我们将探索通过干扰衰老的分子主开关来使这些衰老细胞恢复活力的诱人可能性。一种独特的机器学习方法将被用于寻找最有效的干预措施。这一结果将在女性生育、神经退化和免疫等领域产生广泛的影响，而不仅仅是衰老科学。

Understanding why we age and whether aging is preventable are profound research challenges, which must be first tackled at a cellular level. Building on our advances in non-invasive colour monitoring of cell function, this project aims to uncover intimate links between cellular processes and aging in cells that must survive for many decades such as oocytes and neurons. We will explore the tantalising possibility to rejuvenate such aged cells by interfering with molecular master switches of aging. A unique machine learning approach will be applied for finding the most effective interventions. The results will have broad impact beyond the science of aging, in the areas of female fertility, neurodegeneration and immunity.