Cancer Genetics and Genomics Program

癌症遗传学和基因组学 杜克癌症研究所的癌症遗传学和基因组学（CGG）项目是一个基础科学项目 其目标是确定驱动肿瘤发生的遗传变化，了解肿瘤的起源， 这些变化的后果，并利用所获得的知识，为癌症的诊断和治疗提供信息。 CGG成员使用多样化和互补的实验方法，包括结构生物学， 生物化学、细胞生物学、遗传学和基因组学，并采用模式生物以及临床前模型。 在杜克癌症研究所（DCI）内，CGG项目是遗传学和 基因组学专业知识，广泛促进“组学”技术的应用，以评估癌症的变化 基因组、表观基因组和转录组。因此，该计划协调DCI的研究活动， 研究和理解癌症遗传学、表观遗传学、基因表达、基因组不稳定性和基因组学。 CGG促进与其他DCI计划的互动和合作。 CGG计划分为三个重点小组：（1）基因组学和表观遗传学，（2）纯化， 复制和修复，以及（3）病毒肿瘤学和微生物组。这些焦点小组反映了 促进癌症发展和改变疾病进程的因素。每个焦点小组提供 通过研究进展会议和小型研讨会提供互动和协作的机会。在 此外，每个焦点小组都与促进教育/指导的T32培训补助金密切相关 计划和DCI的目标。CGG通过每月一次的 计划范围的研讨会和季度会议，旨在促进合作和多PI赠款。 CGG计划由来自10个部门的35名主要成员和25名次要成员组成 以及杜克大学的两所学校。主要计划成员的直接资金总额为1030万美元，其中 880万美元经过同行评审，其中包括来自NCI的250万美元。从2014年到2018年，计划成员发表了451篇 在同行评审期刊上发表的论文中，12%是项目内合作，31%是项目间合作。

ABSTRACT – CANCER GENETICS AND GENOMICS PROGRAM The Duke Cancer Institute’s Cancer Genetics and Genomics (CGG) Program is a basic science program whose goals are to define the genetic changes that drive tumorigenesis, to understand the origins and consequences of these changes, and to use the knowledge gained to inform cancer diagnosis and treatment. CGG members use diverse and complementary experimental approaches that include structural biology, biochemistry, cell biology, genetics and genomics and employ model organisms as well as pre-clinical models. Within the Duke Cancer Institute (DCI), the CGG Program serves as the primary source of genetics and genomics expertise and broadly facilitates the application of ‘omics’ technologies to assess alterations in cancer genomes, epigenomes and transcriptomes. As such, the Program coordinates DCI research activities related to the study and understanding of cancer genetics, epigenetics, gene expression, genome instability and genomics. The CGG fosters interactions and collaborations with other DCI programs. The CGG Program is organized into three focus groups: (1) Genomics and Epigenetics, (2) Recombination, Replication and Repair, and (3) Viral Oncology and Microbiomes. These focus groups reflect the diversity of factors that promote the development of cancer and alter the course of the disease. Each focus group provides opportunities for interaction and collaboration through research-in progress meetings and mini-symposia. In addition, each focus group is closely aligned with a T32 training grant that facilitates the education/mentoring goals of the Program and the DCI. The CGG fosters interactions between the focus groups through a monthly program-wide seminar and quarterly meetings designed to foster collaboration and multi-PI grants. The CGG program is comprised of 35 primary members and 25 secondary members from 10 departments and two schools within Duke University. Total direct funding for primary program members is $10.3M, of which $8.8M is peer reviewed, including $2.5M from the NCI. From 2014-2018, program members published 451 papers in peer-reviewed journals, 12% were intra-programmatic and 31% inter-programmatic collaborations.