Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques

项目总结 俄勒冈州国家灵长类研究中心(ONPRC)扩大了SPF(ESPF)猕猴的繁殖 蜂群是一个高度专业化的繁殖群体，为独特而必要的猕猴提供了一个扩展的 艾滋病研究的SPF定义。这个群体对于艾滋病相关的机会性感染研究和 使用机会性病毒制剂作为疫苗载体的疫苗载体的开发。为了提供足够的 适当的动物数量，繁殖群体每年必须生产30只多余的动物。同时，它还 是分离无淋巴腺病毒(LCV)的动物和从LCV中重新获得无LCV的后代所必需的 在群体中进行血清转换的雌性，并从中心的常规SPF招募额外的无LCV婴儿 殖民地。严重缺乏适当的ESPF社会住房严重制约了我们增加 繁殖群体的规模，以满足项目需求和我们从群体中消除LCV的努力。 申请书建议完成对现有西南户外庇护房屋的改造。 提供额外四个500平方米的结构。英国《金融时报》社会保障性住房。拟议的修改将 扩大社会团体饲养的室外ESPF繁殖动物的总数 生产，通过提供更小的住房单元来促进遗传管理， 住房7-10名女性和一名男性及其后代，在各个住房单元之间提供足够的间隔 防止病原体在群体间传播，并通过社会住房改善动物福利。

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's convention SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to complete modifications of the existing southwest outdoor sheltered housing structure providing an additional four 500 sq. ft. social housing units. The proposed modifications would expand the total number of outdoor ESPF breeding animals housed in social groups permitting increased production, facilitate genetic management by providing smaller housing units that are more appropriate for housing 7-10 females and a male and offspring, provide sufficient separation between individual housing units to prevent transmission of agents between groups, and improve animal welfare through social housing.