UF PASS: Regulation of exercise transducers: supplement for diverse students

摘要：本研究增刊的目的是促进健康相关研究的多样性 通过支持布莱恩·阿拉瓦的职业发展培训，布莱恩·阿拉瓦目前是该大学的博士生 佛罗里达大学。这一行政补充将促进应聘者的职业发展 并为母项目的使命-发现新的运动诱导健康-做出贡献 相关结果。父级奖项是MoTrPAC财团的一部分，该财团结合了明确定义的 结合多组学分析的运动干预，以开发一张连接分子转导的图谱 锻炼对全身健康有好处。到目前为止，该联盟正在分析17个不同的多组学数据 作为临床前研究的一部分，按照确定的跑步机运动范例收集的组织。 Alava先生提议的研究的主要目标有两个：第一，使用定义的阿尔茨海默氏症 疾病(AD)小鼠模型的骨骼肌功能和血液标记物的变化 炎症和新陈代谢。其次，一旦确定了特征，我们将使用此模型来测试跑步机 基于MoTrPAC使用的方案的培训方案，用于延缓疾病进展的有效性 广告。我们还将能够访问MoTrPAC提供的更大的多组学数据，以进行扩展 运动和AD病理的潜在分子靶点。Esser博士，U01的PI，将是两个人之一 阿拉瓦先生的主要导师。何塞·阿比桑布拉博士是另一位共同导师，因为他的实验室提供AD 小鼠模型和大脑病理分析方面的专业知识。Esser博士和Abisambra博士已经 布莱恩·阿拉瓦在生理学和医学系博士项目中的官方共同导师 佛罗里达大学医学院的功能基因组学。我们已经概述了一个 一系列指导性和体验式培训活动，将使阿拉瓦先生掌握必要的技能 作为一名独立的科学家取得进步，并完成NIH的使命，推动多元化的职业生涯 科学家的群体。

Abstract: The purpose of this Research Supplement is to Promote Diversity in Health-Related Research through support of the career development training for Bryan Alava, a current PhD student at the University of Florida. This administrative supplement will facilitate career development for the candidate and as well as contribute to the mission of the parent project - to discover novel exercise induced health related outcomes. The parent award is part of the MoTrPAC consortium that combines well defined exercise interventions with multi-omics analysis to develop a map of molecular transducers that link exercise to systemic health. To date, the consortium is analyzing the multi-omics data across 17 different tissues collected following a defined treadmill exercise paradigm as part of the preclinical studies. The primary objectives of Mr. Alava’s proposed research are two-fold: First to use a defined Alzheimer’s Disease (AD) mouse model to characterize changes in skeletal muscle function and blood markers of inflammation and metabolism. Second, once characterized we will use this model to test a treadmill training protocol, based on the protocol used for MoTrPAC, for efficacy in delaying the progression of AD. We will also be in a position to access the larger multiomics data available from MoTrPAC to expand potential molecular targets of exercise and AD pathology. Dr. Esser, the PI of the U01, will be one of two primary mentors for Mr. Alava. Dr. Jose Abisambra is the other co-mentor as his lab provides the AD mouse model and expertise in the analysis of brain pathologies. Drs. Esser and Abisambra are already official co-mentors for Bryan Alava within the Ph.D. program in the Department of Physiology and Functional Genomics within the College of Medicine at the University of Florida. We have outlined a series of didactic and experiential training activities that will equip Mr. Alava with the necessary skills to progress as an independent scientist and to fulfill the NIH mission to advance the careers of a diverse population of scientists.