Cardiorenal and Metabolic Diseases Research Center

整体 项目总结/摘要 心血管（CV）、肾脏和代谢疾病有着千丝万缕的联系，是导致心血管疾病的主要原因。 死亡率和发病率，特别是在密西西比，它是全国发病率最高的州， 这些疾病。肾脏疾病和代谢疾病通常聚集在一起，并且高度相互依赖。 肥胖和相关代谢紊乱（如糖尿病）是CV和肾脏疾病的主要原因。 肾功能异常是高血压的一个重要原因，也是高血压的一个结果，高血压是高血压的一个关键风险因素。 心血管疾病，如冠状动脉疾病和中风。了解CV之间的复杂关系， 肾脏和代谢疾病，并开发新的治疗方法，需要一个范式的转变， 结合多学科综合方法的研究，结合基础，临床和 人口科学家第二阶段COBRE提案的一个主要目标是进一步开发领先的 肾脏和代谢疾病研究中心（CMDRC），汇集了多学科小组 基础，临床和人口科学家致力于共同的协同主题，并促进他们的 合作。具体目标是：1）进一步发展基础设施和核心设施， 在心肾和代谢疾病的基础、临床和人口研究方面取得卓越成就， CMDRC研究人员获得NIH和其他国家生物医学研究机构独立资助的竞争力 研究计划; 2）加强CMDRC的指导和教育计划以及研究支持， 有前途的新调查员，使他们能够成为富有成效的，独立的调查员， 多学科研究团队的有效合作者; 3）实现研究的特定目标 本提案中初级研究者描述的项目，并促进其职业发展; 4）进一步 培养各种博士后研究员，研究生和本科生在切割培训管道 心肾和代谢疾病的研究，使他们成为下一代的研究人员在这方面， 外地;主要重点是征聘和辅导任职人数不足的少数族裔调查员， 与当地机构建立伙伴关系，并利用UMMC的培训计划; 5）加强合作 以及心肾和代谢领域多个学科的知名研究者之间的互动 疾病在UMMC，其他IDEA支持的计划，和外部合作伙伴; 6）加强心肾和 通过招募具有临床和翻译专业知识的新教师，在UMMC进行代谢疾病研究 研究，新兴技术（如体内成像，生物信息学和系统分析）和 CMDRC专业知识存在差距的领域。

OVERALL PROJECT SUMMARY/ABSTRACT Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of CV and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for CV diseases such coronary artery disease and stroke. Understanding the complex relationships among CV, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this Phase 2 COBRE proposal is to further develop a leading Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims are: 1) to further develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of CMDRC investigators for independent funding from NIH and other national biomedical research programs; 2) to enhance CMDRC mentoring and education programs and research support for promising new investigators so that they can become productive, independent investigators who are also effective collaborators on multidisciplinary research teams; 3) to achieve the specific aims of the research projects described by Junior Investigators in this proposal, and to foster their career development; 4) to further develop a pipeline of diverse postdoctoral fellows, graduate and undergraduate students trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis is placed on recruiting and mentoring underrepresented minority investigators through partnerships with local institutions and by leveraging training programs at UMMC; 5) to enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, other IDeA supported programs, and external partners; 6) to strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research, and in emerging technologies (e.g. in vivo imaging, bioinformatics, and systems analysis) and in areas where there are gaps in CMDRC expertise.