Translational Neurophysiology Core

项目摘要：翻译神经生理学核心 翻译神经生理学核心的目的是通过促进交叉项目来将各个项目联系起来 物种、跨方法行为和神经数据的收集和分析。我们的中心依靠标准化 EEG/fMRI采集和处理，以及与人类一致的DPX和BANDIT任务数据收集 对照受试者和患有早期精神病的参与者(项目3和4)。此外，合奏 录音和本地场电位数据以及DPX和Bandit任务行为数据将收集在 非人灵长类(项目1)和小鼠(项目2)。神经记录的跨模式方面 而行为数据采集带来了独特的挑战，将通过三个服务来解决 目标。 服务目标1：支持行为数据采集。我们中心将收集逐个试验的数据 来自相同实验行为范式(DPX和Bandit任务)的人类获得了这两种任务 临床和标准人体样本，在多个环境中进行研究(例如，项目3和4)。这很重要 开发这些范例，以便使用便携式数字设备以高度可靠的方式进行管理 方法，并将从这些范例中收集的数据存储、处理、集成和可视化 以安全、可靠和可访问的方式，以便可以跨项目比较调查结果。 服务目标2：同时采集的脑电的标准化采集、预处理和分析 以及人类的功能核磁共振数据。我们的目标是确保收集、预处理和分析这些数据 在项目3和项目4中采用相同的方式，重点是获取可由 评估活动时间、兴奋-抑制平衡和系统噪声的计算核心。 服务目标3：跨物种神经解剖学翻译。我们将促进神经回路的翻译 通过使用连接数据(扩散磁共振成像和轨迹跟踪相结合)来识别跨物种 非人灵长类动物(项目1)、小鼠(项目2)和人类(项目3和4)的同源性。

PROJECT SUMMARY: TRANSLATIONAL NEUROPHYSIOLOGY CORE The purpose of the Translational Neurophysiology Core is to link the individual Projects by facilitating cross- species, cross-method behavioral and neural data collection and analysis. Our Center relies on standardized EEG/fMRI acquisition and processing, as well as consistent DPX and Bandit task data collection with human control subjects and participants with early psychosis (PROJECTS 3 and 4). In addition, ensemble recordings and local field potential data, along with DPX and Bandit task behavioral data, will be collected in nonhuman primates (PROJECT 1) and mice (PROJECT 2). The cross-modal aspect of neural recordings and behavioral data acquisition presents unique challenges, which will be addressed through three Service Aims. Service Aim 1: Support for behavioral data acquisition. Our Center will collect trial-by-trial data in humans from identical experimental behavioral paradigms (the DPX and Bandit tasks) acquired across both clinical and normative human samples, studied in multiple settings (e.g. PROJECTS 3 & 4). It is important that these paradigms be developed to be administered in a highly reliable manner using portable digital methods, and that the data collected from these paradigms be stored, processed, integrated, and visualized in a secure, reliable, and accessible manner so that findings can be compared across Projects. Service Aim 2: Standardized collection, preprocessing, and analysis of simultaneously acquired EEG and fMRI data in humans. Our goal is to ensure that these data are collected, preprocessed, and analyzed in an identical manner across PROJECTS 3 and 4, with a focus on acquiring measures that can be used by the COMPUTATIONAL CORE to assess activity timing, excitatory-inhibitory balance, and system noise. Service Aim 3: Cross-species neuroanatomical translation. We will facilitate translation of neural circuits across species by using connectivity data (combination of diffusion MRI and tract- tracing) to identify homologies across nonhuman primates (PROJECT 1), mice (PROJECT 2), and humans (PROJECTS 3 & 4).