Southern HIV and Alcohol Research Consortium Administrative and Research Support Core

南方艾滋病毒酒精研究联盟(SHARC)成立于2012年，是五个国家之一 艾滋病毒/艾滋病和酒精研究翻译联合会。SHARC的使命是改善健康 结果和减少在佛罗里达州受酒精和艾滋病毒影响的人的艾滋病毒传播。佛罗里达州拥有世界上 美国新的艾滋病毒感染率最高，艾滋病毒+50岁以上人群的比例不断上升，而且范围广泛 不同年龄、性别、种族/族裔和地域(农村/城市)的人口多样性。 下一阶段的 SHARC(2016-2021) 将侧重于酒精与艾滋病毒传播(包括艾滋病毒病毒)的关系 抑制)和艾滋病毒共病(特别是脑功能和肝病)。 SHARC将由三个人组成 综合建议将：集中我们的行政和研究基础设施(本U24)，确定 酒精对大脑的有害方面是否可逆(U01)，并提供策略方面的专业知识 改变饮酒行为和生物统计分析(U24)。具体地说，这份U24提案将 集中SHARC管理服务，并继续代表 行政性 佛罗里达队列研究表明 SHARC基础设施和协作活动的主干。该队列将成为以下项目的参与者来源 我们的U01研究以及Cohort和U01项目都将得到U24行为/生物统计学的支持 核心。这个U24的具体目标是目标1：E 确保所有人的领导力、协作和科学监督 与SHARC相关的活动。具体地说，核心将： 从执行委员会、科学界人士和 咨询委员会和社区咨询委员会；监督我们的科学贡献和研究 工作效率、 管理日常运营，协调和促进访问SHARC数据和/或 生物样本，提供IRB和监管支持，并传达我们的科学发现。目标2： 支持正在进行的与佛罗里达队列相关的合作研究活动。该队列于2014年发起 并将完成1700人的注册(1500人艾滋病毒+，200人艾滋病毒-)。在这些人中，将有900人感染艾滋病毒 前瞻性地使用酒精消费、神经认知、肝病和艾滋病毒病毒的增强措施 压制。这900人将包括300名酗酒者(女性每周7杯酒，男性每周14杯酒)， 300人有中度饮酒，300人没有目前饮酒。 佛罗里达军团代表着 SHARC基础设施，使我们能够 参与协作研究，将公共卫生环境和 学术机构；b)支持和扩大我们的培训和发展计划；以及c)促进 招募参与者加入我们的伙伴U01 参与者联系人注册表 。饮酒的范围很广 队列内的行为和种群多样性将允许 美国将比较酗酒对健康的影响 艾滋病毒对不同人群和社区的影响。 通过与至少8家不同的公共卫生机构合作 全州的诊所和机构，我们现在准备在一系列干预和 针对个人、公共卫生诊所和机构的实施研究。

The Southern HIV Alcohol Research Consortium (SHARC) was established in 2012 as one of five national Consortia for HIV/AIDS and Alcohol Research Translation. The mission of SHARC is to improve health outcomes and reduce HIV transmission in persons affected by alcohol and HIV in Florida. Florida has the highest rate of new HIV infections in the US, a growing proportion of HIV+ persons over age 50, and broad population diversity across age, gender, race/ethnicity, and geography (rural/urban). The next phase of SHARC (2016-2021) will focus on the relationship of alcohol to HIV transmission (including HIV viral suppression) and HIV comorbidities (especially brain function and liver disease). SHARC will consist of three integrated proposals that will: centralize our administrative and research infrastructure (this U24), determine whether harmful aspects of alcohol on the brain are reversible (U01), and provide expertise in strategies to change drinking behavior and in biostatistical analyses (U24). Specifically, this U24 proposal will centralize SHARC administrative services, and also continue represents the Administrative the Florida Cohort study that backbone of SHARC infrastructure and collaborative activity. The Cohort will be the source of participants for our U01 research, and both the Cohort and U01 projects will be supported by the U24 behavioral/biostatistical core. The specific aims of this U24 are Aim 1: E nsure leadership, collaboration, and scientific oversight for all activities related to SHARC. Specifically, the Core will: obtain input from an Executive Committee, a Scientific Advisory Board, and a Community Advisory Board; monitor our scientific contributions and research productivity, manage day-to-day operations, coordinate and facilitate requests to access SHARC data and/or biological samples, provide IRB and regulatory support, and communicate our scientific findings. Aim 2: Support ongoing collaborative research activity related to the Florida Cohort. The Cohort was initiated in 2014 and will complete enrollment of 1700 persons (1500 HIV+, 200 HIV-). Of these, 900 HIV+ will be tracked prospectively using enhanced measures of alcohol consumption, neurocognition, liver disease, and HIV viral suppression. These 900 will include 300 with heavy drinking (> 7 drinks/week women, >14 drinks/week men), 300 with moderate drinking, and 300 with no current drinking. The Florida Cohort represents the backbone of SHARC infrastructure that allows us to a) engage in collaborative research that links public health settings and academic institutions; b) support and expand our Training and Development Program; and c) facilitate recruitment of participants into our companion U01 via a participant contact registry . The wide range of drinking behavior and population diversity within the Cohort will allow us to compare the impact of heavy drinking on HIV outcomes across diverse populations and communities. By partnering with at least 8 distinct public health clinics and settings across the state, we are now poised to collaborate on a range of intervention and implementation studies targeting individuals and public health clinics and settings.