Vanderbilt Mouse Metabolic Phenotyping Center

范德比尔特小鼠代谢表型中心(VMMPC)成立于2001年，旨在促进医学和 通过向科学界提供标准化、高质量的表型鉴定服务进行生物学研究 用于糖尿病、糖尿病并发症和肥胖的小鼠模型。VMMPC由五个核心组成。这个 管理核心提供科学、财务和行政领导。该核心还负责监督 服务请求、数据管理和跟踪VMMPC研究的MICE。行政核心也是 负责VMMPC的外展和教育项目。动物健康和福利核心 评估提交给VMMPC的老鼠，监督殖民地的健康和福利，并确保 遵守监管机构和MMPC指南。代谢调节核心提供的服务 (MRC)强调研究意识中的胰岛素作用、激素分泌和新陈代谢的方法论， 没有压力的老鼠。MRC还具有单独评估器官或胰岛功能的复杂能力 并且可以应用最先进的成像技术。体重调节核心有一系列测试来 研究能量平衡的决定因素。这些指标包括能量消耗、摄食行为、体力活动、 身体成分、线粒体功能和减肥手术程序。分析资源核心 (ARC)接收VMMPC测试和在外部进行的实验生成的样本 VMMPC。ARC执行的分析特定于鼠标，并进行了扩展以适应较小的 样本量。ARC服务的范围从激素、分析物、脂质、脂蛋白和 动脉粥样硬化病变到创新的代谢流量分析。VMMPC的存在是因为对 NIDDK的领导力，范德比尔特大学学院慷慨的空间和资源承诺 医药，以及精心设计的基础设施。但VMMPC运行良好的主要原因是 因为组成它的人。VMMPC的存在是因为它的教职员工愿意 向科学界和工作人员提供的技术和指导，他们的技能和奉献精神如此之高 科学家们愿意把他们的老鼠和有价值的样本委托给他们。

The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and biological research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The Administrative Core provides scientific, financial, and administrative leadership. This Core also oversees service requests, data management, and tracks mice studied at the VMMPC. The Administrative Core is also responsible for the VMMPC outreach and educational program. The Animal Health and Welfare Core evaluates mice submitted to the VMMPC, oversees the health and welfare of the colony, and ensures compliance with regulatory bodies and MMPC guidelines. Services provided by the Metabolic Regulation Core (MRC) emphasize methodology to study insulin action, hormone secretion, and metabolism in the conscious, unstressed mouse. The MRC also has a sophisticated capacity to assess organ or islet function in isolation and can apply state-of-the-art imaging techniques. The Body Weight Regulation Core has a range of tests to study determinants of energy balance. These include energy expenditure, feeding behavior, physical activity, body composition, mitochondrial function, and bariatric surgery procedures. The Analytical Resources Core (ARC) receives samples generated from VMMPC testing and from experiments conducted outside the VMMPC. Analyses performed by the ARC are specific to the mouse and are scaled to accommodate small sample volumes. ARC services range from assessment of hormones, analytes, lipids, lipoproteins, and atherosclerotic lesions to innovative metabolic flux analysis. The VMMPC exists because of the insight of leadership at the NIDDK, a generous commitment of space and resources from Vanderbilt University School of Medicine, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is because of the people that comprise it. The VMMPC exists because of a faculty that is willing to make technology and guidance available to the scientific community and a staff that is so skilled and committed that scientists are willing to entrust their mice and valuable samples with them.