Core G Neuropath

神经病理学核心-核心G：项目摘要/摘要 BIOCARD研究是一项纵向的观察性研究，对349名认知正常和 注册时主要为中年(平均年龄为57.1岁)。这些受试者现在已经被跟踪了长达27年。 该项目的总体目标是进一步推进临床前阿尔茨海默病的研究 通过：(1)澄清AD生物标志物(包括基于脑脊液、血液、MRI、 和PET成像)和认知；待研究的生物标记物包括几个有前途的新生物标记物 从血液、脑脊液和脑成像中提取。(2)通过与多家公司协作，最大限度地利用我们的数据 拥有可比较数据的研究小组，以及(3)提供公开可访问的数据、脑扫描和 生物标本，供该领域的研究人员使用。为了实现这些目标，我们建立了7个核心， 本申请，还包括2个项目。神经病理核心(核心G)负责 监督BIOCARD研究参与者的脑组织神经病理学评估 并确保将这些调查结果与其他核心收集的相关数据结合起来， 项目。具体目标包括：(1)维持潜在脑捐赠者的登记；(2)安排和 进行神经病理尸检，(3)提供神经病理诊断，(4)整合神经病理学 与来自其他核心和项目的数据一起的数据，(5)，以准备、存储和分发尸检脑组织 研究，以及(6)继续研究阿尔茨海默病的早期发病机制。

NEUROPATHOLOGY CORE – CORE G: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Neuropathology Core (Core G) is responsible for overseeing the neuropathological assessment of brain tissue from participants in the BIOCARD study and for assuring the integration of these findings with relevant data collected by the other Cores and Projects. The specific aims include: (1) to maintain a registry of prospective brain donors, (2) to arrange and perform neuropathologic autopsies, (3) to provide neuropathologic diagnoses, (4) to integrate neuropathology data with data from other Cores and Projects, (5), to prepare, store and distribute autopsy brain tissue for research, and (6) to continue investigations of the early pathogenesis of Alzheimer’s disease.