Neural, Computational, and Neuromechanical Approaches to Motor Control

摘要 芝加哥大学在运动控制方面的研究和培训具有将神经生物学和 用计算方法进行神经力学研究。在过去的几年里，该大学已经 通过建立新的神经科学研究所，大大扩大了其神经科学界。 这些重大投资为以下领域的研究和培训创造了令人兴奋的新机会 运动控制和运动及相关障碍，特别是在通过整合解决问题方面 实验和计算方法。 我们的培训计划将利用现有的运动控制和运动的广度和深度 在校园里进行研究。我们有15名训练员，他们的研究重点是运动控制和运动， 涵盖从遗传、分子和细胞研究到电路、系统、生物力学和 计算方法。我们的研究兴趣广泛，从神经肌肉连接 脊髓到小脑、基底节和大脑皮层。我们采用了广泛的模型 包括无脊椎动物、昆虫、斑马鱼和老鼠在内的生物体向非人类灵长类和人类受试者传播。 在评估参加培训方案的候选人时，一个标准将是他们表现出对衔接的兴趣 实验和计算工作作为他们论文的一个要素。学员将完成以下内容 程序元素。1.《电机控制研究中的实验设计》课程。2.一次或两次旋转 这扩大了对方法的敞口。3.年度问题解决工作坊。4.杂志俱乐部强调 统计方法。通过活动，我们将汇聚师生，他们的工作主要是 试验性的和那些工作是计算性的。我们将作为一个社区探索如何 电机控制中的问题可以在不同的方法水平上解决。除了实习生 在T32的支持下，我们将增加准会员，以便任何从事电机控制工作的实习生 研究或对运动控制研究感兴趣的可以参加T32赞助的活动。所有实习生都将 掌握统计方法方面的关键技能。整个培训过程中将强调写作和演示技巧。 我们培训计划中的教员主要在五个系(神经病学、神经生物学、 生物生物学和解剖学、分子遗传学和细胞生物学、麻醉学和重症监护)，以及 在五个参与的研究生课程中的一个或多个中的一个或多个中的预约(神经生物学； 计算神经科学；遗传学、基因组学和系统生物学；综合生物学；医学科学家 培训计划)。 我们建议支持6名博士前实习生(从第一年的3个名额开始)。将为学生提供以下支持 在第三年和第四年的研究生培训中有两年的时间。我们每年将任命3名新的实习生。

ABSTRACT Research and training on motor control at UChicago have a unique history of combining neurobiology and neuromechanics research with computational approaches. In the past few years, the University has significantly expanded its neuroscience community with the establishment of the new Neuroscience Institute. The significant investments have created exciting new opportunities for research and training in the area of motor control and movement and related disorders, especially in addressing questions by integrating experimental and computational approaches. Our training program will take advantage of the existing breadth and depth of motor control and movement research on campus. We have 15 Trainers whose research is focused on motor control and movement, covering a broad range from genetic, molecular and cellular studies to circuit, systems, biomechanics and computational approaches. Our research interests have a broad anatomic scope, from neuromuscular junction and spinal cord to cerebellum, basal ganglia and cerebral cortex. We employ a broad range of model organisms including invertebrates, insects, zebrafish and mice to non-human primates and human subjects. In evaluating candidates for the Training Program, a criterion will be their demonstrated interest in bridging experimental and computational work as an element of their dissertations. Trainees will complete the following Program Elements. 1. The “Experimental Design in Motor Control Research” course. 2. One or two rotations that broaden exposure to approaches. 3. Annual problem-solving workshop. 4. Journal club that emphasizes statistical methods. With the activities, we will bring together faculty and students whose work is mainly experimental and those whose work is computational. We will explore as a community how fundamental questions in motor control can be addressed at a range of levels of approach. In addition to the trainees supported by the T32, we will add Associate Members so that any trainee who is working on motor control research or is interested in motor control research could participate in T32 sponsored activities. All trainees will gain key skills in statistics methods. Writing and presentation skills will be emphasized throughout the training. Faculty in our Training Program have primary appointments in five departments (Neurology, Neurobiology, Organismal Biology and Anatomy, Molecular Genetics and Cell Biology, Anesthesia and Critical Care), and appointments in one or more than one of the five participating Graduate Programs (Neurobiology; Computational Neuroscience; Genetics, Genomics and Systems Biology; Integrative Biology; Medical Scientist Training Program). We propose to support 6 predoctoral trainees (starting with 3 slots in year 1). Students will be supported for 2 years during years 3 and 4 of their graduate training. We will appoint 3 new trainees every year.